Targeting on hydrodesulphurization, hydrodenitrification and hydrodemetallization from inferior VGO, hydrotreating experiments were conducted to investigate the effect of various hydrotreating conditions on the quality of the hydro-products. Meanwhile, variation of the components and its corresponding change of macroscopic properties were also analyzed on the basis of three types of inferior VGO. The rates of hydrodesulfurization, hydrodenitrogenation and hydrodemetallization were improved with the increase of reaction temperature. Compared with raw oil, hydrogenated oil has a low 95% point distillation temperature and density, and the content of sulfur, nitrogen and metal in the produced oil is greatly reduced.